Ketamine therapy for PTSD
A six-infusion course of ketamine over two weeks reduced PTSD (post-traumatic stress disorder) symptoms more than an active placebo in a randomized trial, with effects lasting several weeks in responders. Results across studies are mixed and durability is limited without maintenance, so it is best used as an adjunct to trauma-focused psychotherapy. Commercial insurance, Medicare, and Medicaid do not cover it.
Updated · Checked by the Covered Mind editorial team against cited sources
What the evidence shows for ketamine in post-traumatic stress disorder, who is a candidate, what a course looks like, and why it is usually cash pay.
Key facts
- Last checked:
- Sources listed: 1
- Reading time: About 1 minute
- Trial course: six infusions over two weeks
- Typical course: Six infusions over two to three weeks
- Cash price: $350 to $850 per infusion
- Coverage: Not covered by commercial insurance, Medicare or Medicaid
| Fact | Value |
|---|---|
| Last checked | |
| Sources listed | 1 |
| Reading time | About 1 minute |
| Trial course | six infusions over two weeks |
| Typical course | Six infusions over two to three weeks |
| Cash price | $350 to $850 per infusion |
| Coverage | Not covered by commercial insurance, Medicare or Medicaid |
What does the evidence say about ketamine therapy for PTSD?
Repeated IV ketamine infusions reduced PTSD symptoms more than an active placebo in a randomized trial of six infusions over two weeks, with effects lasting several weeks in responders. Results across studies are mixed and durability is limited without maintenance, so ketamine for PTSD is best framed as an adjunct to trauma-focused psychotherapy.
See what your plan requires in the coverage checker and read ketamine coverage by insurer. Common questions about coverage and billing are answered on the ketamine therapy overview.
Who is a candidate for ketamine therapy for PTSD?
Adults with chronic PTSD who have not improved with first-line treatments (trauma-focused CBT, EMDR, SSRIs), without contraindications to ketamine. Many clinics pair infusions with therapy sessions because the window after dosing appears to help processing.
What does ketamine therapy for PTSD involve?
Six infusions over two to three weeks, then boosters. Some programs use ketamine-assisted psychotherapy formats instead.
See ketamine-assisted psychotherapy explained and Ketamine therapy: the complete guide.
Does insurance cover ketamine therapy for PTSD, and what does it cost?
Not covered by commercial insurance, Medicare or Medicaid. Some VA facilities offer ketamine for veterans with treatment-resistant depression and PTSD; ask your VA mental health clinic. Cash prices run $350 to $850 per infusion.
See the ketamine therapy overview and Spravato for PTSD.
Related
Checked by the Covered Mind editorial team · · Editorial policy
Cite this
Covered Mind. "Ketamine therapy for PTSD." https://www.coveredmind.com/conditions/ptsd/ketamine-therapy. Last checked Sep 1, 2026.
This site provides general information about insurance coverage and treatment options. It is not medical advice, not a guarantee of coverage, and not a substitute for talking with a clinician or your health plan.