Ketamine therapy for anxiety

What does the evidence say about ketamine therapy for anxiety?

Small trials report reduced generalized and social anxiety symptoms for days to weeks after ketamine, and several ketamine clinics treat anxiety off label. The evidence is thinner and less consistent than for depression, and no guideline recommends ketamine as a first-line or second-line anxiety treatment.

See the coverage hub, the ketamine therapy hub, and the coverage checker.

Who is a candidate for ketamine therapy for anxiety?

Adults with severe, treatment-resistant anxiety, most often with co-occurring depression, who have completed a trial of evidence-based psychotherapy and two or more medications. Clinics should measure anxiety with a rating scale (GAD-7) and stop if there is no response.

What does ketamine therapy for anxiety involve?

Six infusions or a KAP program with therapy. Anxiety during the dissociative phase is common; preparation and a calm setting matter more here than in depression treatment.

Read Ketamine therapy: the complete guide.

Does insurance cover ketamine therapy for anxiety, and what does it cost?

Not covered. Cash prices run $350 to $850 per session.

See the ketamine therapy overview, side effects and safety and Spravato for anxiety.

See Ketamine vs esketamine: how they differ.

Read Ketamine-assisted psychotherapy explained and At-home ketamine vs in-clinic treatment.