Ketamine therapy for treatment-resistant depression
What the evidence shows for ketamine in treatment-resistant depression, who is a candidate, what a course looks like, and why it is usually cash pay.
Updated · Checked by the Covered Mind editorial team against cited sources
Key facts
- Last checked:
- Sources listed: 1
- Reading time: About 1 minute
- Course: Six infusions over two to three weeks
- Cash price: $350 to $850 per infusion
- Coverage: Not covered by insurance.
| Fact | Value |
|---|---|
| Last checked | |
| Sources listed | 1 |
| Reading time | About 1 minute |
| Course | Six infusions over two to three weeks |
| Cash price | $350 to $850 per infusion |
| Coverage | Not covered by insurance. |
Why is ketamine therapy used for treatment-resistant depression?
Most ketamine trials enrolled people with treatment-resistant depression, and the response rates in that population (50 to 70 percent for an initial series) are what made ketamine notable. It works through a different mechanism than antidepressants, so prior medication failures do not predict ketamine failure.
See the coverage hub, the ketamine therapy hub, and the coverage checker.
When do clinicians choose ketamine therapy over Spravato?
When a patient does not meet Spravato's insurance criteria, cannot take an oral antidepressant, has been denied, or when a ketamine clinic is nearer or cheaper for them. Some clinicians also prefer IV dosing for its adjustability.
See Spravato vs ketamine: which is right for you?
What does ketamine therapy for treatment-resistant depression involve?
Six infusions over two to three weeks, then boosters at increasing intervals. A rating scale before and after the series tells you and the clinic whether to continue.
Read Ketamine therapy: the complete guide.
Does insurance cover ketamine therapy for treatment-resistant depression, and what does it cost?
Not covered by insurance. Cash prices run $350 to $850 per infusion.
See ketamine therapy cost and compare with Spravato for TRD.
Related
Checked by the Covered Mind editorial team · · Editorial policy
Cite this
Covered Mind. "Ketamine therapy for treatment-resistant depression." https://www.coveredmind.com/conditions/treatment-resistant-depression/ketamine-therapy. Last checked Sep 1, 2026.
This site provides general information about insurance coverage and treatment options. It is not medical advice, not a guarantee of coverage, and not a substitute for talking with a clinician or your health plan.